.406 Ventures
Boston, MABoston-based venture capital firm investing in early-stage technology companies with over $1.4B under management.
90+ venture capital firms, angel groups, and startup funds in Boston and Cambridge investing in early-stage companies. Curated for founders from MIT and Harvard.
Boston and Cambridge are home to one of the most active venture capital ecosystems in the United States, second only to the San Francisco Bay Area. With deep ties to MIT and Harvard, the Boston VC scene is uniquely positioned for founders building technology, deep tech, life sciences, and AI companies.
Boston-based venture capital firm investing in early-stage technology companies with over $1.4B under management.
Seed-stage fund investing in technical founders building enterprise AI and deep tech. Backs companies at the intersection of AI, data, and enterprise software.
Thesis-driven pre-seed and seed fund investing in Vertical AI, Deep Tech, Healthcare and Biotech startups in NYC and Boston.
Bold early-stage investor with deep roots in Boston's tech ecosystem. Formerly Atlas Venture's tech arm.
Invests in early-stage emerging B2B technology companies. Has backed 110+ companies since 1985. Six funds totaling $500M under management.
Boston-based venture firm writing checks for pre-seed through Series A startups in software, marketplaces, fintech, and digital health.
Boston-based family office founded in 2015 that invests only its own principals' capital in high-quality companies with significant long-term.
Major Boston-headquartered venture arm of Bain Capital investing from seed through IPO. 94 seed investments with average round size of $4.85M.
Invests in early-stage, fast-growing New England companies with a sweet spot around $225K. Over $185M AUM with successful exits across sectors.
One of America's oldest venture capital firms ($4B AUM) investing from seed through growth. Strong Boston presence in Cambridge/MIT/Harvard corridor.
Group of proven business leaders investing in high-growth early-stage companies since 2004. Seeks capital-efficient businesses that can reach profitability.
One of the first dedicated institutional seed funds in Boston (2010). Founded by deeply Boston-rooted entrepreneurs.
Venture capital fund exclusively for MIT alumni investing in companies with an MIT connection. Part of Alumni Ventures, the largest venture fund for individuals.
A venture capital fund exclusively for MIT alumni and friends of the MIT community, part of Alumni Ventures.
Cambridge-based venture studio and seed investor that builds and invests in data-driven companies using proprietary data science and machine learning capabilities.
Lower middle-market private equity firm investing in growth-stage tech-enabled services companies across IT services, cloud consulting, and digital advertising.
Early-stage B2B technology investor at pre-seed, seed, and Series A. Sweet spot around $1.5M. Founded by experienced female GPs with deep operating backgrounds.
Originally founded in 1998 as CommonAngels, one of Boston's pioneering angel groups. Evolved into a venture fund in 2015, closing a $27M fund.
Founded in 1970 to commercialize MIT research. Specializes in early-stage seed and Series A startups with deep technical roots across enterprise and consumer.
Private investment arm of FMR LLC, the parent company of Fidelity Investments. Boston-based family office investing in fintech, IT, and communications.
Student-run venture fund backed by First Round Capital that invests in the best student-run startups.
Founded in 1985 by Tim Draper, a seed-stage venture firm with 60+ unicorns including Tesla, Skype, and Hotmail.
Cross-border venture capital focusing on seed and growth investments for companies seeking internationalization between Brazil and the United States.
Early-stage deep tech fund from and for the MIT Media Lab startup community. Named after the MIT Media Lab building (E14).
Invests in 'tough tech' companies translating breakthrough science and engineering from lab to market.
MIT-born fund investing in 'tough tech' that translates breakthrough science and engineering from lab to market.
Global venture capital firm with a 50+ year legacy rooted in Fidelity Investments. Backs groundbreaking companies in healthcare and technology from seed.
Cambridge-based venture capital firm investing in ethical technologies and companies aligned with social impact principles.
Seed fund investing in deep tech spinouts from MIT, Harvard, and other leading research universities. Backs founders commercializing scientific breakthroughs.
Pre-seed fund backing first-time technical founders building ambitious companies. Focus on capital-efficient startups in software and deep tech.
Cambridge-based life sciences venture firm that builds companies from scratch internally. Created Moderna and originated 100+ scientific ventures.
Global VC investing in early-stage tech companies with a strong MIT and Harvard network. Backs founders across cybersecurity, AI, and enterprise software.
East Coast seed firm backing the AI-powered future. Partners make 8-10 investments per fund. Also operates Next Wave pre-seed funds with 50+ founder-operators.
Pre-seed funds where 50+ founders/operators from Anthropic, NVIDIA, OpenAI run independent investment vehicles that Flybridge anchors.
Seed-stage venture fund with a mission of being the most aligned fund for founders. Founded by three HBS graduates who co-founded and sold Brontes Technologies.
Seed-stage fund focused on B2B enterprise technology. Invests in founders building software platforms for large, underserved markets.
Student-run fund backed by General Catalyst investing at the earliest stage in student-founded startups.
Major multi-stage firm headquartered in Cambridge investing from seed through growth. Backs Rough Draft Ventures for student founders.
Student-run pre-seed venture capital fund supporting early-stage startups founded by student entrepreneurs from Harvard, MIT, BU, Northeastern, and Babson.
First-capital-in venture firm dedicated to building the future of enterprise and security through AI and frontier technology.
Leading angel network funding women-led startups for 20+ years. $190M+ invested in 260+ women-led companies across all chapters.
Alumni Ventures fund for Dartmouth alumni investing across stages. Cross-invests with other Alumni Ventures funds for broad portfolio diversification.
Harvard's innovation ecosystem offering workspace, mentorship, and venture competitions. Includes equity-free grants backed by Bain Capital and General Catalyst.
Forum for all Harvard alumni to connect with, learn about, and invest in early-stage companies in Boston and New England.
Massachusetts-based investment firm (founded 1987) investing in seed, early and growth-stage companies in consumer and enterprise technology.
One of the oldest and most experienced angel groups in Boston, investing in young tech and life science companies in the Northeastern United States since 2000.
Corporate venture arm of HubSpot investing in early-stage companies building for growing businesses. Focus on go-to-market, commerce, and AI.
Seed-stage firm backing bold founders from day zero since 2015. Focus on companies building the automated future across AI, ML, and emerging technology sectors.
Venture arm of IDEO investing in emerging technology at the seed stage. Backs founders building at the intersection of design and technology.
Pre-seed fund investing in overlooked founders and markets. Backs diverse founding teams building across sectors with broad market potential.
Cambridge-based early-stage venture fund investing in technology startups across enterprise software, AI, and emerging platforms.
Seed investment firm (since 2008) investing across nearly every industry. Pritzker/Vlock Family Office backing provides growth investment capability.
Network of active angel investors building individual portfolios by investing both financial and human capital in New England-based startups.
Cambridge-based firm backing elite technical founders from MIT and Harvard building transformational AI companies.
Corporate venture arm of MassMutual investing in fintech, insurtech, and enterprise tech startups. Leverages MassMutual's industry expertise.
Quasi-public venture fund investing in academic spinouts and early-stage deep tech companies in Massachusetts.
Long-established early-stage firm with Cambridge, MA office specializing in seed and early-stage investments.
Early-stage venture fund investing at pre-seed to Series A in B2B software companies, vertical agnostic with focus on helping founders build durable.
Angel investing group bringing together investors and entrepreneurs in the MIT ecosystem. Screens startups founded by MIT alumni, faculty, and students.
Seed-stage fund focused on redesigning the 'everyday economy' - how people live, work, and thrive. Five equal partners making 1-4 investments yearly.
Early-stage seed to Series A venture fund investing in technology-driven companies across AI, fintech, and workforce management.
Founder-first seed fund launched in 2025 by Giuseppe Stuto, co-founder of 186 Ventures, backing founders with unconventional backgrounds across AI, healthcare, fintech and consumer.
World's largest EdTech-focused venture capital firm with $2.2B+ AUM across seven funds. Invests at every stage in companies transforming the future of learning.
$25M pre-seed and seed fund for dual-use technology bridging government and commercial markets, covering defense, AI, cybersecurity and advanced materials. Founded by Nicholas Maynes.
Invests in technical breakthroughs and exceptional founders at pre-seed and seed. Co-founded by a group of CEOs who have built highly successful companies.
Experienced Boston venture firm with a startup mindset. Seeks to be the first institutional capital deployed, offering Seed and Series A funding.
Venture capital firm with some of the closest ties to academia in the industry. MIT serial entrepreneur Robert Langer has started 20+ companies with Polaris.
Impact-driven fund investing in climate and deep tech solutions. Backs founders building technologies that address environmental challenges.
Invests in startups creating solutions for the ocean and climate. Focuses on maritime, aquaculture, and sustainability technology ventures.
Pre-seed to seed stage venture fund focused on HealthTech and Enterprise Infrastructure, based in Boston with experienced venture partners.
Family office of Jim Pallotta, former Vice Chairman of Tudor Investment Corporation. Actively invests across seed, growth, and late-stage companies.
Revenue-based financing and equity for diverse-led startups. Provides non-dilutive and flexible capital to underrepresented founders in Boston.
Cambridge-based early-stage fund focused on deep tech and life sciences. Invests in companies translating research into breakthrough products.
Deep technology venture capital firm leading 6-8 institutional seed rounds per year. Invests across all venture stages from $500K pre-seed to $100M growth.
MIT-born venture capital firm focused on seed and early-stage technology. Leads Seed and Series A rounds for B2B companies and deep tech spinouts from MIT.
Student-run pre-seed fund backed by General Catalyst that invests $25K in startups founded by students or recent graduates.
Growth capital investment firm founded in 1971 investing in seed through growth stage companies in healthcare and technology sectors in the United States.
Generalist early-stage VC founded by early Facebook employees. $800M+ deployed since 2011. Avg seed check ~$1.75M.
Multi-stage venture firm with deep Boston roots. 67 seed investments with average round size of $4.9M. Offices in San Francisco, New York, and Boston.
Early-stage healthcare venture fund investing in digital health, medical devices, life sciences, and tech-enabled care delivery, founded by repeat.
Boston College-focused seed-stage venture fund and accelerator for alumni and student entrepreneurs, providing funding and mentorship.
Corporate venture arm of Suffolk Construction investing in built world technology. Backs startups transforming construction, real estate, and infrastructure.
Boston-based angel group backing early-stage founders across technology sectors. Provides capital and mentorship to pre-seed and seed startups.
Top accelerator providing $220K total investment ($20K for 5% equity + $200K uncapped MFN Safe), plus mentorship, workspace, and lifetime network.
Cybersecurity-focused venture capital firm investing from seed to growth. One of the few dedicated cybersecurity VCs with a Boston presence.
Robert Kraft's family office with 100+ venture and private equity investments. Long history of backing technology and consumer companies in the Boston area.
Private investing community for Harvard alumni featuring a diversified venture fund and deal-by-deal syndications.
Early-stage investment group within TiE Boston (founded 1997 by successful entrepreneurs of Indian origin).
Early-stage AI and software fund investing at pre-seed and seed, emphasizing capital-efficient startups positioned to create massive impact by.
One of the original micro-VC firms (2004). Commits early, helps with the hard stuff, and sticks around. Added Boston as a geographic focus in 2014.
Solo GP fund run by Salil Deshpande with $750M+ AUM. Invests across pre-seed, seed, and Series A with sweet spot around $1M.
Boston-based firm backing bold B2B software entrepreneurs at pre-seed and seed. Sweet spot around $2.5M.
Seed and early-stage fintech investor using exclusive access to Cogo Labs' petabyte-scale consumer data and proprietary ML models to predict which.
Pre-seed accelerator and fund backing underrepresented founders in tech. Provides $50K investment, mentorship, and community for diverse entrepreneurs.
Seasoned entrepreneurs and executives who invest, mentor, and partner with seed-stage companies in New England since 1997.
Seed fund focused on developer-first companies. Backs technical founders building tools, infrastructure, and platforms for software developers.
Early-stage venture capital fund anchored at Harvard University. Invests in outstanding founders affiliated with Harvard, MIT, and other leading universities.
A private investing community exclusively for Harvard alums, featuring both a diversified venture fund and deal-by-deal syndications.
We're always looking to connect founders with investors who want to support the next generation of startups from MIT and Harvard.
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